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Table 3 Top 3 annotation clusters enriched in proestrus versus diestrus common between RNA-sequencing and Chromatin immunoprecipitation-sequencing analyses

From: The estrous cycle surpasses sex differences in regulating the transcriptome in the rat medial prefrontal cortex and reveals an underlying role of early growth response 1

Cluster enrichment score

Term

Count

p-value

Fold enrichment

Cluster #1: 2.72

Synapse

14

3.07E−08

7.24

 

Cell junction

13

1.27E−06

5.82

 

Plasma membrane

29

1.77E−06

2.37

 

Plasma membrane part

21

4.06E−06

3.03

 

Synapse part

10

4.81E−06

7.56

 

Postsynaptic membrane

7

5.92E−05

10.01

 

Synaptic transmission

7

5.03E−04

6.78

 

Cell-cell signaling

8

7.78E−04

5.14

 

Transmission of nerve impulse

7

1.90E−03

5.25

 

Exocytosis

5

2.01E−03

9.14

 

Postsynaptic density

4

8.24E−03

9.44

 

Secretion by cell

5

1.51E−02

5.15

 

Neurotransmitter secretion

3

2.41E−02

12.24

 

Secretion

5

3.49E−02

3.97

 

Vesicle-mediated transport

6

5.15E−02

2.91

 

Regulation of neurotransmitter levels

3

5.77E−02

7.58

 

Neurotransmitter transport

3

7.82E−02

6.36

 

Generation of a signal involved in cell-cell signaling

3

8.78E−02

5.95

 

Regulation of cellular localization

4

1.37E−01

3.06

 

Protein domain specific binding

4

1.99E−01

2.55

 

Regulation of secretion

3

3.14E−01

2.60

 

Neurological system process

9

6.40E−01

1.03

Cluster #2: 2.30

Biological adhesion

9

1.23E−03

4.12

 

Cell adhesion

9

1.23E−03

4.12

 

Cell-cell adhesion

4

8.08E−02

3.87

Cluster #3: 1.74

Postsynaptic membrane

7

5.92E−05

10.01

 

Cytoskeleton

11

1.70E−02

2.29

 

Cytoskeletal part

9

2.15E−02

2.54

 

Intracellular non-membrane-bounded organelle

12

2.99E−01

1.29

 

Non-membrane-bounded organelle

12

2.99E−01

1.29