Global DNA methylation in human adipose tissue plotted by gene region. Gene regions are based on Illumina 450 K beadchip annotation. Data are presented as mean +/− standard deviation. *Significant difference between average DNA methylation before and after weight loss, Bonferroni adjusted P <0.05. TSS proximal promoter defined as 200 bp (TSS200) or 1,500 bp (TSS1500) upstream of the transcription start site. UTR: untranslated region. Ab – subcutaneous adipose, Om – omentum before (pre) and after (post) gastric bypass and weight-loss.