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Figure 2 | Genome Biology

Figure 2

From: Identification of novel fusion genes in lung cancer using breakpoint assembly of transcriptome sequencing data

Figure 2

Genomic complexity of EML4-ALK co-occurring fusion genes. (a) Detection by transcriptome sequencing of SOS1-ADCY3 and SND1-CFTR in the H3122 and H2228 EML4-ALK-positive cell-lines, respectively. Schematic representation of the fusion transcripts and some of the transcriptome sequencing reads spanning the fusion point. (b) Top: schematic representation of part of chromosome 2 illustrating the location of ADCY3, ALK, SOS1, and EML4 as well as the relative location of the FISH probes. Bottom, from left to right: ADCY3 break-apart assay, ALK break-apart assay, and simultaneous application of ADCY3 and ALK break-apart assays on metaphase chromosomes of H3122 cells.

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Genome Biology

ISSN: 1474-760X

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