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Table 3 Amino acid substitutions that are the predominant change in the virus population analysed at passage 5

From: Elucidating variations in the nucleotide sequence of Ebola virus associated with increasing pathogenicity

NP

          
 

566

         

EBOV

N

         

P1

N

         

P2

S

         

P3

S

         

P4

S

         

P5

S

         

VP35

          
 

204

         

EBOV

N

         

P1

D

         

P2

D

         

P3

D

         

P4

D

         

P5

D

         

No amino acid mutations for VP40

        

sGP

          
 

49

203

        

EBOV

D

V

        

P1

?

?

        

P2

?

I

        

P3

N

I

        

P4

N

I

        

P5

N

I

        

No amino acid mutations for VP30

        

VP24

          
 

26

         

EBOV

L

         

P1

F

         

P2

F

         

P3

F

         

P4

F

         

P5

F

         

L

          
 

38

707

930

940

1271

1478

1546

1998

2144

2151

EBOV

N

G

T

L

Y

N

A

S

N

F

P1

?

?

?

?

?

?

?

?

N

-

P2

N

?

T

L

Y

N

A

S

N

V

P3

N

?

T

L

Y

N

A

S

N

V

P4

N

G

T

L

Y

N

A

?

N

V

P5

K

A

A

P

STOP

H

E

T

K

V

L

          
 

2186

         

EBOV

M

         

P1

-

         

P2

M

         

P3

M

         

P4

M

         

P5

T

        Â