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Figure 1 | Genome Biology

Figure 1

From: Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations

Figure 1

Inter-rater agreement between 15 mutation effect prediction algorithms. Hierarchical clustering of the calls made by 15 mutation effect prediction algorithms using (A) all 3,591 single nucleotide variants (SNVs) included in this study, and (C) the 1,699 SNVs not present in the COSMIC database. The unweighted Cohen’s Kappa coefficient was computed for each pair of predictors using (B) all 3,591 SNVs and (D) the 1,699 SNVs not present in the COSMIC database. The ranges of unweighted Kappa values and their corresponding colors are indicated in the color key.

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Genome Biology

ISSN: 1474-760X

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