Figure 7
From: Mammalian conserved ADAR targets comprise only a small fragment of the human editosome
Editing and exonization in the SLC9A6 gene. (A) Schematic illustration of exons 12 to 14 of the SLC9A6 gene. Exons are depicted as blue boxes; the LINE inverted repeats are depicted as red boxes. Sense and antisense LINEs are expected to create a dsRNA secondary structure, thereby allowing RNA editing. The two editing sites are indicated in orange, revealing an R/G amino acid change. (B) Validation of editing by Sanger sequencing, genomic DNA (upper panel) and cDNA (lower panel) from the same individual; editing sites are marked by arrows.