Skip to main content

Table 3 AgeCGs and nonageCGs affiliated with gene expression within tissues classified by CpG context a

From: Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape

 

AgeCGs/genesb

Non-ageCGs/genesc

P-valued

Expressed

Non-expressed

Expressed

Non-expressed

 

Blood

     

  All

271 (46.2)

315 (53.8)

4610 (78.4)

1270 (21.6)

<2.2 × 10-16 *

  Island only

121 (36.1)

214 (63.9)

2251 (89.0)

277 (11.0)

<2.2 × 10-16 *

  Shore only

101 (72.7)

38 (27.3)

1610 (83.5)

317 (16.5)

1.5 × 10-3 *

  Other only

49 (43.8)

63 (56.2)

749 (52.6)

676 (47.4)

0.09

Brain

     

  All

591 (78.8)

159 (21.2)

4404 (89.3)

528 (10.7)

3.5 × 10-16 *

  Island only

328 (79.4)

85 (20.6)

2243 (97.0)

70 (3.0)

<2.2 × 10-16 *

  Shore only

184 (85.6)

31 (14.4)

1564 (95.0)

82 (5.0)

1.2 × 10-7 *

  Other only

79 (64.8)

43 (35.2)

597 (61.4)

376 (38.6)

0.53

Kidney

     

  All

1209 (77.4)

354 (22.6)

4046 (89.9)

456 (10.1)

<2.2 × 10-16 *

  Island only

402 (71.2)

163 (28.8)

2089 (97.5)

54 (2.5)

<2.2 × 10-16 *

  Shore only

440 (85.8)

73 (14.2)

1362 (95.0)

71 (5.0)

1.1 × 10-11 *

  Other onlye

367 (75.7)

118 (24.3)

595 (64.3)

331(35.7)

1.6 × 10-5 *

Muscle

     

  Allf

515 (77.2)

152 (22.8)

2784 (71.8)

1095 (28.2)

4.2 × 10-3

  Island only

258 (78.4)

71 (21.6)

1262 (87.3)

184 (12.7)

5.2 × 10-5 *

  Shore only

142 (86.1)

23 (13.9)

1065 (82.0)

233 (18.0)

0.24

  Other only

115 (66.5)

58 (33.5)

457 (40.3)

678 (59.7)

1.6 × 10-10 *

  1. aExpressed genes, FPKM > 0.25; non-expressed genes, FPKM < 0.05. Parentheses indicate percentage of total in each CpG context category.
  2. b,cGenes in proximity to an ageCG or non-ageCG according to the smallest age-associated P-value for representative genes in each tissue.
  3. dResulting P-values from Pearson’s Chi-squared tests between numbers of ageCGs and non-ageCGs within each classification.
  4. eAgeCGs/genes found within CGOs from kidney showed a significantly greater number of expressed genes compared to non-ageCGs in kidney.
  5. fMuscle was the only tissue that showed a greater number of total ageCGs/genes expressed compared to non-ageCGs/genes regardless of CpG contextthis same effect was observed within the CGO category.
  6. *Significant P-values meet Bonferroni correction for multiple testing.
Back to article page

Genome Biology

ISSN: 1474-760X

Contact us