Figure 4

CTCF and YY1 bind to distinct repetitive elements across primate species with no evidence of lineage-specific expansions. (A) Significant CTCF binding event associations with repeat elements. MY, million years ago. (B) LTR13 and LTR41 repeat profiles centered on the summit of significantly associated CTCF binding events across primate species. (C) Significant YY1 binding event associations with repeat elements. Pol II, RNA polymerase II. (D) MLT1F and MLT1J repeat profiles centered on the summit of significantly associated YY1 binding events across primate species. (E) CTCF and Pol II ChIP-seq binding profiles in a 10 kb window around LTR13 and LTR41/LTR50 repeat elements in H.sap LCLs and H.sap liver. (F) YY1 and Pol II ChIP-seq binding profiles in a 10 kb window around MLT1F/MLT1J repeat elements in H.sap LCLs and H.sap liver. For panels A and C only associations with a -log P-value >10 in at least one species are shown; the color intensity represents the association's significance. Repeat elements are sorted by estimated age from youngest to oldest and primate species by evolutionary distance from human.