Figure 6

Single-cell co-expression analysis identifies putative regulatory interactions between key modules. (A) The co-expression network at 24 h reveals two modules that are highly interconnected. (B) The temporal changes in expression and variation of all TFs in module 1 and module 2. (C) The quantification of regulatory edges based on the RNAi-network reveals higher number of upstream genes for module 1 while opposite is true for module 2. (D) The transcription factor binding site (TFBS) analysis reveals a significant over-representation of AP1 (JUN) motif in module 1 as compared to all other motifs found in module 2 (# P value <0.05).