Figure 3From: A comparative analysis of exome captureExome coverage, based on RefSeq sequences, was incomplete with exome capture but nearly complete with whole genome resequencing. (a) Since the CCDS only includes very well annotated protein-coding regions, we assessed exome kit coverage of the more comprehensive RefSeq sequences, which include protein-coding exons, non-coding exons, 3' and 5' UTRs, and non-coding RNAs, and encompass 65,545,985 bp of genomic space. Coverage of RefSeq sequences by the exome kits was clearly incomplete, with at most 50% of RefSeq covered at 1× depth or greater. (b) In contrast, coverage of RefSeq by whole genome data from the trio pilot of the 1000 Genomes Project was nearly complete, with approximately 98% of RefSeq covered at 1× or greater and approximately 94% covered at 20× or greater from the more deeply sequenced daughter samples. This plot uses an identical format to the one used in Figure 2; see the caption of Figure 2 for detailed description.Back to article page