Table 2 Point mutations identified in the cancer mini-exome of patients 1 to 4

From: Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer

	Patient 1		Patient 2		Patient 3		Patient 4
Gene	TC	LM	TC	LM	TC	LM	TC	LM
APC	5:112175523 T/-	5:112175523 T/-	E1536* (5:1121758970)	E1536* (5:1121758970)	Y1376* (5:112175419)	Y1376* (5:112175419)	5:112128152 C/-	R499* (5:112162891)
			R876* (5:112173917)	R876* (5:112173917)
DDR2				H340D (1:162731163)
KRAS			G12A (12:25398284)	G12A (12:25398284)				G12A (12:25398284)
PTPRF			D562G (1:44058144)	D562G (1:44058144)
SMAD2				R321* (18:45374882)
SMAD4				L495P (18:48604662)
TP53					R273C (17:7577121)	R273C (17:7577121)	R175H (17:7578406)	C275W (17:7577113)
MLL3	I155T (7:152012349)	I155T (7:152012349)
PARP14	Q1332P (3:122437236)	Q1332P (3:122437236)
PIK3CA	E545K (3: 178936091)	E545K (3: 178936091)					E545K (3: 178936091)
KDR			R1032* (4:55956221)
PRKCD				T419I (3:53220352)
RFC1			4:39290432 T/C
EXOC4	K765R (7:133682332)
TSC1					R288C (9:135787720)
FGFR2	R399* (10:123274723)	R399* (10:123274723)
NUP98					H1647D (11:3704460)	H1647D (11:3704460)
ERBB3			V104M (12:56478854)	V104M (12:56478854)
RASA3				V117M (13:114806499)
DNAH9			R4106H (17:11837216)
TAOK1	K484M (17:27835026)	K484M (17:27835026)
ATRX							X:76845412 +A
TTN	K13350N (2:179445230)			H8533Y (2:179571272)
				E4246K (2:179604510)
EPHA4				2:222298957 +T

TC, colon tumor; LM, liver metastasis. Genomic coordinates are based on the hg19 genome build.

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