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Table 2 Point mutations identified in the cancer mini-exome of patients 1 to 4

From: Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer

  Patient 1 Patient 2 Patient 3 Patient 4
Gene TC LM TC LM TC LM TC LM
APC 5:112175523 T/- 5:112175523 T/- E1536* (5:1121758970) E1536* (5:1121758970) Y1376* (5:112175419) Y1376* (5:112175419) 5:112128152 C/- R499* (5:112162891)
    R876* (5:112173917) R876* (5:112173917)     
DDR2     H340D (1:162731163)     
KRAS    G12A (12:25398284) G12A (12:25398284)     G12A (12:25398284)
PTPRF    D562G (1:44058144) D562G (1:44058144)     
SMAD2     R321* (18:45374882)     
SMAD4     L495P (18:48604662)     
TP53      R273C (17:7577121) R273C (17:7577121) R175H (17:7578406) C275W (17:7577113)
MLL3 I155T (7:152012349) I155T (7:152012349)       
PARP14 Q1332P (3:122437236) Q1332P (3:122437236)       
PIK3CA E545K (3: 178936091) E545K (3: 178936091)      E545K (3: 178936091)  
KDR    R1032* (4:55956221)      
PRKCD     T419I (3:53220352)     
RFC1    4:39290432 T/C      
EXOC4 K765R (7:133682332)        
TSC1      R288C (9:135787720)    
FGFR2 R399* (10:123274723) R399* (10:123274723)       
NUP98      H1647D (11:3704460) H1647D (11:3704460)   
ERBB3    V104M (12:56478854) V104M (12:56478854)     
RASA3     V117M (13:114806499)     
DNAH9    R4106H (17:11837216)      
TAOK1 K484M (17:27835026) K484M (17:27835026)       
ATRX        X:76845412 +A  
TTN K13350N (2:179445230)    H8533Y (2:179571272)     
     E4246K (2:179604510)     
EPHA4     2:222298957 +T     
  1. TC, colon tumor; LM, liver metastasis. Genomic coordinates are based on the hg19 genome build.