Table 1 Immune signaling pathway statistics
From: NetPath: a public resource of curated signal transduction pathways
| Â | Pathway | Molecular association events | Catalysis events | Transport events | Total reactions | Number of upregulated genes annotated | Number of downregulated genes annotated | Number of PubMed links |
|---|---|---|---|---|---|---|---|---|
1 | T cell receptor | 202 | 215 | 13 | 430 | 453 | 178 | 1,153 |
2 | B cell receptor | 172 | 136 | 43 | 351 | 253 | 182 | 990 |
3 | IL-1 | 55 | 44 | 9 | 108 | 161 | 79 | 461 |
4 | IL-2 | 68 | 76 | 11 | 155 | 539 | 301 | 1289 |
5 | IL-3 | 65 | 52 | 5 | 122 | 43 | 10 | 250 |
6 | IL-4 | 59 | 47 | 5 | 111 | 222 | 90 | 519 |
7 | IL-5 | 26 | 40 | 6 | 72 | 167 | 9 | 308 |
8 | IL-6 | 65 | 58 | 7 | 130 | 84 | 25 | 332 |
9 | IL-7 | 14 | 39 | 2 | 55 | 57 | 14 | 175 |
10 | IL-9 | 14 | 20 | 4 | 38 | 25 | 1 | 103 |
Total | 10 | 740 | 727 | 105 | 1,572 | 2,004 | 889 | 5,580 |