Table 4 Summary of signaling modules
From: Integrated analysis of breast cancer cell lines reveals unique signaling pathways
| Â | Number of rules | Key component(s) | Summary of key events |
|---|---|---|---|
1 | 1 | Pi3k, ErbB4 | ErbB4 activation of Pi3k |
2 | 1 | Snca | Pyk2 activation of Snca |
3 | 1 | Caml, Rsk | Rsk activation of Caml |
4 | 1 | Stat3 | Stat3 activation by EgfR |
5 | 1 | Irs, Pi3k | Irs activation of Pi3k |
6 | 1 | Rela | Formation of Ikba, Nfkb1, Rela complex |
7 | 2 | Pik3ca-mut | Akt signaling through Pi3k mutant |
8 | 2 | Mef2c | Camk activation of Mef2c |
9 | 2 | IL11R, Jak | IL11R activation of Jak |
10 | 2 | Elmo, Rac1 | Elmo activation of Rac1 |
11 | 2 | Abi1, Pir121 | Wave1 activation dependent on Abi1 and Pir121 |
12 | 3 | Mylk | Mylk activation of Mlc |
13 | 3 | RhoB | RhoB activation |
14 | 3 | EsR1, Bcat | EsR1 activation by Rsk; Bcat activation |
15 | 3 | Fos | Fos activation by Erk |
16 | 3 | Bcat | Activation and degradation of Bcat |
17 | 4 | Cav1, UpaR | Integrin/Cav1 activation of Shc; UpaR activation |
18 | 5 | Pten, Kras, Pik3ca | Mutation rules |
19 | 5 | ErbB4 | ErbB4 activation of ErbB2, Shc; Grb2 relocation |
20 | 6 | PrlR | PrlR signaling |
21 | 7 | Irs1 | Irs1 activation; Grb2 translocation |
22 | 8 | Pi3k | Eight ways to activate Pi3k |
23 | 12 | RhoB | RhoB activation of first-order effectors |
24 | 12 | Cbl | Cbl-related signaling, including Rap1a, Crk, Dock |
25 | 14 | Src | Src-related signaling, including Fak, Pax, Cas |
26 | 15 | EgfR | First-order EgfR interactions including ErbB2, Grb2, Cbl |
27 | 16 | Efna1 | EphA2/Efna1 signaling; Integrin deactivation by EphA2 |
28 | 27 | ErbB3 | ErbB3 activation by Nrg1 and ErbB2; ErbB3 activation of Shc |
29 | 32 | EgfR, Src | Src-dependent activation of EgfR; Cdc42 signaling; activation of Src effectors |
30 | 76 | Src, Rac1-GTP | Rac1 signaling; MAPK activation |