From: Gene expression regulation in the context of mouse interspecific mosaic genomes
Genes with modified mRNA level between SEG and B6 | ||||||||
---|---|---|---|---|---|---|---|---|
Gene name | Induction ratio IRCS/B6 | Length of B6 promoter (bp) | Length of SEG promoter (bp) | Number of sequence differences | Percentage of sequence divergence | Total number of TFBSs detected with Genomatix | Number of TFBSs differing between M. spretus and M. musculus | Percentage of TFBS differing between M. spretus and M. musculus |
Pde7a | 0.02 | 749 | 728 | 29 | 3.87 | 137 | 21 | 15.33 |
Aldh1a7 | 0.04 | 598 | 587 | 11 | 1.84 | 101 | 30 | 29.70 |
1810058I14rik | 0.05 | 638 | 613 | 28 | 4.39 | 100 | 38 | 38.00 |
Plcz1 | 0.09 | 1,432 | 1,392 | 42 | 2.93 | 228 | 51 | 22.37 |
Itga2 | 0.10 | 769 | 749 | 21 | 2.73 | 94 | 14 | 14.89 |
Nol9 | 0.11 | 1,034 | 1,021 | 15 | 1.45 | 198 | 32 | 16.16 |
4833412L08Rik | 0.12 | 601 | 583 | 18 | 3.00 | 106 | 20 | 18.87 |
4921521F21Rik | 0.16 | 603 | 597 | 7 | 1.16 | 137 | 8 | 5.84 |
Plek | 4.34 | 698 | 679 | 27 | 3.87 | 134 | 33 | 24.63 |
Cast | 5.28 | 648 | 629 | 21 | 3.24 | 101 | 22 | 21.78 |
Slc6a3 | 5.94 | 657 | 650 | 7 | 1.07 | 90 | 16 | 17.78 |
Hnf4g | 6.64 | 601 | 589 | 14 | 2.33 | 105 | 29 | 27.62 |
6130401L20Rik | 7.22 | 758 | 743 | 26 | 3.43 | 138 | 53 | 38.41 |
Mbl2 | 7.45 | 629 | 615 | 14 | 2.23 | 101 | 24 | 23.76 |
E030010A14 | 10.06 | 622 | 600 | 33 | 5.31 | 143 | 63 | 44.06 |
Hebp1 | 10.19 | 604 | 596 | 9 | 1.49 | 83 | 11 | 13.25 |
Pcsk1 | 20.74 | 839 | 834 | 5 | 0.60 | 110 | 9 | 8.18 |
Slc6a19 | 23.39 | 667 | 648 | 22 | 3.30 | 96 | 22 | 22.92 |
Pdcd1lg2 | 38.40 | 662 | 647 | 17 | 2.57 | 88 | 20 | 22.73 |
Mean | 726.8 | 710.5 | 19.3 | 2.7 | 120.5 | 27.2 | 21.6 | |
Standard deviation | 201.9 | 197.4 | 9.9 | 1.2 | 37.9 | 15.2 | 11.1 | |
Genes with unchanged mRNA level between SEG and B6 | ||||||||
Tle4 | 1.19 | 1,289 | 1,284 | 5 | 0.39 | 250 | 5 | 2.00 |
Bhlhb5 | 1.20 | 791 | 788 | 3 | 0.38 | 165 | 11 | 6.67 |
Cypt12 | 1.07 | 603 | 593 | 12 | 1.99 | 161 | 14 | 8.70 |
Spag16 | 0.81 | 511 | 506 | 6 | 1.17 | 87 | 13 | 14.94 |
Zmat5 | 0.94 | 619 | 610 | 9 | 1.45 | 90 | 18 | 20.00 |
Mean | 762.6 | 756.2 | 7.0 | 1.1 | 150.6 | 12.2 | 10.5 | |
Standard deviation | 311.2 | 312.3 | 3.5 | 0.7 | 66.9 | 4.8 | 7.1 | |
p -value | NS | NS | 0.008 | 0.016 | NS | 0.019 | 0.023 |