Table 3 Transcription factors with predicted binding motifs over-represented in HK gene promoters
From: Housekeeping genes tend to show reduced upstream sequence conservation
Transcription factor | Description | Expression breadth |
|---|---|---|
AHR and ARNT | Aryl hydrocarbon receptor; it can interact with ARNT (AHR:ARNT heterodimer) | INT |
ATF family | Activating transcription factor | HK |
CREB family | cAMP responsive element binding protein | INT |
E2F family | E2F transcription factor | INT and HK |
HIF1A | Hypoxia inducible factor 1, alpha subunit; as AHR, it can interact with ARNT | HK |
MYC and MAX | Proto-oncogene protein c-myc and MYC associated factor X; they can form MYC:MAX heterodimers | INT and HK |
NRF1 and NRF2 | Nuclear respiratory factor 1 and 2 | INT and HK |
SP1 | SP1 transcription factor | HK |
USF | Upstream transcription factor (USF1 and USF2) | INT |