Housekeeping genes tend to show reduced upstream sequence conservation

Farré, Domènec; Bellora, Nicolás; Mularoni, Loris; Messeguer, Xavier; Albà, M Mar

doi:10.1186/gb-2007-8-7-r140

Table 2 Average promoter divergence values (d_SM) for HK and non-HK genes classified in different GO classes

From: Housekeeping genes tend to show reduced upstream sequence conservation

		All			CpG+			CpG-
GO term	Description	N	d_SM (HK)	d_SM (nonHK)	N	d_SM (HK)	d_SM (nonHK)	N	d_SM (HK)	d_SM (nonHK)
Molecular function
GO:0000166	Nucleotide binding	464	0.727	0.699	363	0.732	0.698	101	0.684	0.700
GO:0004872	Receptor activity	259	0.734	0.675	131	0.747	0.656	128	0.655	0.692
GO:0004871	Signal transducer activity	440	0.689	0.658	246	0.692	0.656	194	0.663	0.661
GO:0003700	Transcription factor activity	183	0.673	0.602	113	0.657	0.600	70	0.766	0.605
GO:0043169	Cation binding	485	0.711	0.671	308	0.732	0.670	177	0.582	0.671
Biological process
GO:0044249	Cellular biosynthesis	256	0.765	0.735	183	0.781	0.729	73	0.629	0.741
GO:0045184	Establishment of protein transport	162	0.720	0.737	138	0.723	0.731	24	0.677	0.760
GO:0007049	Cell cycle	188	0.697	0.706	152	0.703	0.724	36	0.656	0.646
GO:0019538	Protein metabolism	700	0.748	0.703	523	0.755	0.698	177	0.682	0.713
GO:0044260	Cellular macromolecule metabolism	761	0.748	0.705	560	0.755	0.700	201	0.686	0.713
GO:0050874	Organismal physiological process	292	0.795	0.681	109	0.813	0.675	183	0.756	0.685
GO:0009605	Response to external stimulus	209	0.676	0.711	85	0.758	0.699	124	0.538	0.718
GO:0007166	Cell surface receptor linker signal transduction	221	0.683	0.626	113	0.659	0.645	108	0.762	0.609
GO:0048513	Organ development	214	0.677	0.566	103	0.699	0.528	111	0.633	0.598
GO:0009653	Morphogenesis	262	0.679	0.584	132	0.685	0.549	130	0.664	0.615
GO:0009607	Response to biotic stimulus	166	0.761	0.723	74	0.783	0.686	92	0.680	0.745
GO:0007165	Signal transduction	563	0.684	0.656	342	0.687	0.668	221	0.666	0.643
Cellular component
GO:0005739	Mitochondrion	171	0.785	0.756	148	0.780	0.770	23	0.869	0.707
GO:0005737	Cytoplasm	773	0.756	0.719	579	0.759	0.727	194	0.728	0.707
GO:0005783	Endoplasmic reticulum	153	0.791	0.713	112	0.776	0.712	41	0.881	0.713
GO:0005576	Extracellular region	219	0.653	0.621	77	0.718	0.591	142	0.523	0.635
GO:0005886	Plasma membrane	373	0.720	0.661	189	0.735	0.656	184	0.663	0.666

Entries in bold are those that have a significantly different d_SM distribution (p < 0.05). The number of genes (N) is indicated for each GO class. Results for CpG+ and CpG- genes are shown.

Back to article page

ISSN: 1474-760X

Contact us

Submission enquiries: editorial@genomebiology.com
General enquiries: info@biomedcentral.com

Genome Biology

Contact us