From: GSMN-TB: a web-based genome-scale network model of Mycobacterium tuberculosismetabolism
Gene | Prediction | Â | Knock-out mutant | Â | Reference |
---|---|---|---|---|---|
 | GSMN-TB | TraSH | Species | Phenotype |  |
AftA | E | E | C. glutamicum | Slow growth | [60] |
AroK | E | E | M. tuberculosis | Essential | [79] |
Ask | E | E | M. smegmatis | Auxotroph | [80] |
CysH | E | E | M. smegmatis | Auxotroph | [81] |
GlnA1 | E | E | M. tuberculosis | Essential | [82] |
GlnA3 | NE | NE | M. tuberculosis | Nonessential | [82] |
GlnA4 | NE | NE | M. tuberculosis | Nonessential | [82] |
hemZ | E | E | M. tuberculosis | Essential | [83] |
InhA | E | NE | M. smegmatis | Ts lethal | [31] |
ino1 | NE | NE | M. tuberculosis | Auxotroph | [84] |
KasA | NE | E | M. smegmatis | Essential | [85] |
LeuD | E | E | M. tuberculosis | Auxotroph | [86] |
LysA | E | E | M. tuberculosis | Auxotroph | [87] |
manA | E | E | M. smegmatis | Hyperseptation and loss of viability | [88] |
mshB | NE | NE | M. tuberculosis | Grows poorly | [89] |
mshC | NE | E | M. tuberculosis | Essential | [90] |
murD | E | E | M. tuberculosis | Nonessential | [82] |
murI | E | NE | M. tuberculosis | Nonessential | [82] |
Ndh | NE | NE | M. smegmatis | Ts lethal | [91] |
NrdF2 | E | E | M. tuberculosis | Essential | [92] |
OtsA | E | E | M. tuberculosis | Slow growth | [93] |
OtsB2 | NE | E | M. tuberculosis | Essential | [93] |
panCD | E | NE | M. tuberculosis | Auxotroph | [94] |
panCD | E | E | M. tuberculosis | Auxotroph | [94] |
PimA | E | NE | M. smegmatis | Essential | [95] |
PurC | E | E | M. tuberculosis | Auxotroph | [96] |
Purl | E | E | M. tuberculosis | Auxotroph | [96] |
RmlB | NE | E | M. smegmatis | Essential | [97] |
TreS | NE | NE | M. tuberculosis | Nonessential | [93] |