Table 1 Frequency of GO terms for each group of 'new genes'

Prokaryota

   GO:0050875

Cellular physiological process

3,219

8,198

0

   GO:0008152

Metabolism

2,576

5,906

0

   GO:0044237

Cellular metabolism

2,369

5,566

0

   GO:0044238

Primary metabolism

2,192

5,312

0

   GO:0043170

Macromolecule metabolism

1,569

3,298

0

   GO:0044260

Cellular macromolecule metabolism

1,158

2,500

0

   GO:0019538

Protein metabolism

1,149

2,486

0

   GO:0044267

Cellular protein metabolism

1,138

2,469

0

   GO:0000166

Nucleotide binding

1,070

1,577

0

   GO:0016787

Hydrolase activity

1,037

1,876

0

Eukaryota

   GO:0005622

Intracellular

1,820

6,664

0

   GO:0043226

Organelle

1,587

5,789

0

   GO:0043229

Intracellular organelle

1,586

5,785

0

   GO:0043227

Membrane-bound organelle

1,419

5,097

0

   GO:0043231

Intracellular membrane-bound organelle

1,417

5,092

0

   GO:0005634

Nucleus

1,054

3,267

0

   GO:0046914

Transition metal ion binding

644

1,791

0

   GO:0008270

Zinc ion binding

619

1,416

0

   GO:0004888

Transmembrane receptor activity

23

2,007

0

   GO:0043169

Cation binding

799

2,589

3.45 × e^-85

Metazoa

   GO:0016020

Membrane

1,768

6,163

0

   GO:0031224

Intrinsic to membrane

1,524

4,932

0

   GO:0016021

Integral to membrane

1,523

4,930

0

   GO:0007154

Cell communication

1,234

3,201

0

   GO:0007165

Signal transduction

1,211

3,059

0

   GO:0004872

Receptor activity

1,143

2,793

0

   GO:0007166

Cell surface receptor linked signal transduction

1,061

2,253

0

   GO:0004888

Transmembrane receptor activity

926

2,007

0

   GO:0007186

G-protein coupled receptor protein signaling pathway

906

1,763

0

   GO:0004930

G-protein coupled receptor activity

870

1,693

0

Deuterostomia

   GO:0004931

ATP-gated cation channel activity

5

6

4.74 × e^-05

   GO:0009607

Response to biotic stimulus

45

979

0.00100739

   GO:0006952

Defense response

44

950

0.00100739

   GO:0004800

Thyroxine 5'-deiodinase activity

3

3

0.002093473

   GO:0030106

MHC class I receptor activity

5

15

0.002209497

   GO:0006955

Immune response

35

736

0.002495027

   GO:0030178

Negative regulation of Wnt receptor signaling pathway

4

9

0.003585659

   GO:0042981

Regulation of apoptosis

16

246

0.003971402

   GO:0008430

Selenium binding

6

29

0.004113225

   GO:0008517

Folic acid transporter activity

3

4

0.004113225

Chordata

   GO:0005911

Intercellular junction

38

131

5.96 × e^-33

   GO:0005921

Gap junction

20

24

1.97 × e^-29

   GO:0030054

Cell junction

38

164

2.28 × e^-29

   GO:0005922

Connexon complex

17

18

2.57 × e^-27

   GO:0005243

Gap-junction forming channel activity

17

18

2.57 × e^-27

   GO:0015285

Connexon channel activity

17

18

2.57 × e^-27

   GO:0005923

Tight junction

17

60

2.44 × e^-14

   GO:0016327

Apicolateral plasma membrane

17

76

1.45 × e^-12

   GO:0043296

Apical junction complex

17

76

1.45 × e^-12

   GO:0005615

Extracellular space

74

2,021

7.43 × e^-10

Vertebrata

   GO:0005102

Receptor binding

130

507

0

   GO:0016503

Pheromone receptor activity

59

111

0

   GO:0005179

Hormone activity

53

115

0

   GO:0042221

Response to chemical stimulus

90

329

9.81 × e^-79

   GO:0009628

Response to abiotic stimulus

92

414

2.94 × e^-59

   GO:0005615

Extracellular space

230

2,021

1.24 × e^-45

   GO:0005550

Pheromone binding

50

94

1.49 × e^-38

   GO:0005125

Cytokine activity

52

212

5.02 × e^-38

   GO:0005549

Odorant binding

50

99

3.45 × e^-37

   GO:0001664

G-protein-coupled receptor binding

36

47

3.23 × e^-36

Mammalia

   GO:0005615

Extracellular space

198

2,021

6.14 × e^-53

   GO:0005102

Receptor binding

80

507

1.79 × e^-46

   GO:0005125

Cytokine activity

48

212

1.79 × e^-46

   GO:0009607

Response to biotic stimulus

104

979

1.03 × e^-30

   GO:0006952

Defense response

102

950

1.03 × e^-30

   GO:0042742

Defense response to bacteria

34

70

2.51 × e^-28

   GO:0009617

Response to bacteria

34

78

2.22 × e^-26

   GO:0005126

Hematopoietin/interferon-class (D200-domain) cytokine receptor binding

20

33

6.10 × e^-19

   GO:0008083

Growth factor activity

26

141

2.98 × e^-18

   GO:0051707

Response to other organism

60

594

1.67 × e^-15