Figure 2

Patterns of transcript abundance as a function of illness day (days post-onset of fever). (a) Average transcript abundance of the two gene clusters associated with segregation of the acute and convalescent samples in cohort 1 (yellow bars in Figure 1). Closed symbols indicate pretreatment samples; open symbols indicate post-treatment samples. Black squares and red triangles represent transcripts expressed at higher (cluster 1) and lower (cluster 2) levels in acute KD, respectively. Solid (acute) and dashed (subacute and convalescent) black lines and red lines show the trend in expression levels of the genes in cluster 1 and cluster 2, respectively. (b,c) Average transcript abundance of (b) gene cluster 1 and (c) gene cluster 2 in cohort 2. The significance of the trend of expression over time in cohort 2 (p = 0.01 in (b), and p = 0.03 in (c)) was determined using Spearman rank correlations.