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Figure 1 | Genome Biology

Figure 1

From: Combinatorial RNA interference in Caenorhabditis elegans reveals that redundancy between gene duplicates can be maintained for more than 80 million years of evolution

Figure 1

Combinatorial RNA interference (RNAi) can target two genes in the same animal. Exposing worms to a mixture of two double-stranded (ds)RNA-expressing bacterial clones, one targeting lin-31 and the other one targeting sma-4, resulted in small worms with multiple vulvae along their ventral side. Shown are RNAi-hypersensitive rrf-3 animals [19] fed on bacteria expressing (a) a nontargeting dsRNA (control) and (b) combined bacterial clones expressing dsRNA against lin-31 and sma-4 (magnified in (c)). Pseudovulvae are indicated by white arrowheads.

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Genome Biology

ISSN: 1474-760X

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