From: Evolutionary conservation of domain-domain interactions
Organisma | E. coli | yeast | worm | fly | human |
---|---|---|---|---|---|
Number of PPIsb | 6,934 | 24,699 | 5,315 | 24,703 | 28,800 |
Number of PPIs with known domainsc (N) | 6,038 | 18,202 | 3,351 | 14,939 | 25,004 |
Number of PPIs to which DDIs could be mappedd (n) (%; n/N*100) Median value of random networks (P value) | 806 (13%) 295 (<0.001) | 1,660 (9%) 363 (<0.001) | 375 (11%) 142 (<0.001) | 891 (6%) 276 (<0.001) | 4,924 (20%) 911 (<0.001) |
No. of PPIs to which DDIs could be mapped, disregarding PPI-DDI mappings due to overlap between the structural database and the PPI data (n)(%; n/N*100) Median value of random networks (P value) | 755 (13%) 288 (<0.001) | 1608 (9%) 353 (<0.001) | 375 (11%) 142 (<0.001) | 889 (6%) 276 (<0.001) | 3,989 (16%) 856 (<0.001) |