How complete are current yeast and human protein-interaction networks?

Table 4 Prediction of the size of the human interactome

Dataset pair	Interactions in both datasets	Estimated interactions in common search space	Projected interactome size (95% CI)
Rual-Lehner (core) [14,40]	35	28,200	261,000 (191,000-369,000)
Rual-Rhodes [14,23]	59	20,200	189,000 (154,000-239,000)
Mean			225,000 (154,000-369,000)*

*The range of interactome sizes is the minimum and maximum from the confidence intervals (CI) generated from pairwise estimates.

ISSN: 1474-760X