From: The SET-domain protein superfamily: protein lysine methyltransferases
 | Chromosomal location | Gene size (kb) | Number of coding exons | Protein size (amino acids) | Domains common to the family in addition to the SET domain | Domains unique to particular members | GenBank accession number |
---|---|---|---|---|---|---|---|
SUV39 family | Â | Â | Â | Â | Pre-SET (9 Cys, 3 Zn), post-SET (CXCX4C) | Â | Â |
SUV39H1 | Xp11.23 | 12.4 | 6 | 412 | Â | 4 Cys, chromo | 4507321 |
SUV39H2 | 10p13 | 24 | 6 | 477 (Mm)* | Â | 4 Cys, chromo | 9956936 |
G9a | 6p21.33 | 17.3 | 28 | 1,210 | Â | E/KR-rich, NRSF-binding, ankyrin repeats | 18375637 |
GLP1 (EuHMT1) | 9q34.3 | 120 | 25 | 1,267 | Â | Same as G9a | 20372683 |
ESET (SETDB1) | 1q21.2 | 37 | 21 | 1,291 | Â | Tudor, MBD | 505110 |
CLLL8 (SETDB2) | 13q14.2 | 40 | 14 | 719 | Â | MBD | 13994282 |
SET1 family | Â | Â | Â | Â | Post-SET (CXCX4C) | Â | Â |
MLL1 (HRX, ALL1) | 11q23.3 | 86 | 36 | 3,969 | Â | AT hook, Bromo PHD, CXXC | 1170364 |
HRX2 (MLL4) | 19q13.12 | 20 | 37 | 2,715 | Â | Same as above | 12643900 |
ALR (MLL2) | 12q13.12 | 34 | 54 | 5,262 | Â | PHD, ring finger | 2358285 |
MLL3 | 7q36.1 | 299 | 58 | 4,911 | Â | PHD, ring finger | 21427632 |
SET1 (ASH2) | 16p11.2 | 26 | 18 | 1,707 | Â | RRM, poly-S/E/P | 6683126 |
SET1L | 12q24.31 | 14 | 11 | 1,092 (Mm)* | Â | RRM, poly-S/E/P | 23468263 |
SET2 family | Â | Â | Â | Â | Pre-SET (7-9 Cys); post-SET (CXCX4C) | Â | Â |
WHSC1 (NSD2) | 4q16.3 | 79 | 21 | 1,365 | Â | PWWP, PHD, HMG, ring finger | 6683809 |
WHSCL1 (NSD3) | 8p12 | 73 | 23 | 1,437 | Â | PWWP, PHD, ring finger | 13699811 |
NSD1 | 5q35.3 | 160 | 23 | 2,696 | Â | PWWP, PHD, ring finger | 19923586 |
HIF1 (HYPB) | 3p21.31 | 106 | 19 | 2,061 | Â | WW | 12697196 |
ASH1 | 1q22 | 184 | 27 | 2,969 | Â | AT hook, bromo, BAH, PHD | 7739725 |
RIZ family | Â | Â | Â | Â | Â | Â | Â |
RIZ (PRDM2) | 1p36.21 | 86 | 9 | 1,719 | Â | C2H2 zinc finger | 9955379 |
BLIMP1 (PRDM1) | 6q21 | 19 | 6 | 789 | Â | C2H2 zinc finger | 3493158 |
SMYD family | Â | Â | Â | Â | Post-SET (CXCX2C) | Â | Â |
SMYD3 | 1q44 | 758 | 12 | 428 | Â | Zf-MYND | 30913569 |
SMYD1 | 2p11.2 | 43 | 9 | 490 | Â | Zf-MYND | 38093643 |
EZ family | Â | Â | Â | Â | Pre-SET (~15 Cys) | Â | Â |
EZH1 | 17q21.2 | 26 | 19 | 747 | Â | 2 SANT | 3334182 |
EZH2 | 7q36.1 | 40 | 19 | 746 | Â | 2 SANT | 3334180 |
SUV4-20 family | Â | Â | Â | Â | Post-SET (CXCX2C) | Â | Â |
SUV4-20H1 | 11q13.2 | 57 | 9 | 876 | Â | Â | 50659081 |
SUV4-20H2 | 19q13.42 | 8 | 8 | 462 | Â | Â | 31543168 |
Others | Â | Â | Â | Â | Â | Â | Â |
SET7/9 | 4q31.1 | 45 | 8 | 366 | Â | MORN | 25091213 |
SET8 (PR-SET7) | 12q24.31 | 26 | 8 | 393 | Â | Â | 25091219 |