Table 2 Functional analysis of gene expression differences between autopsy and resection samples
From: Systematic analysis of gene expression in human brains before and after death
GO ID | Term | Expressed genes | Significant differences* | Change p value | Conservation p value |
|---|---|---|---|---|---|
GO:0006412 | Protein biosynthesis | 462 | 101 (37/64) | 0.001 | 0.999 |
GO:0006512 | Ubiquitin cycle | 473 | 119 (86/33) | 0.000 | 1.000 |
GO:0016567 | Protein ubiquitination | 256 | 60 (41/19) | 0.002 | 0.999 |
GO:0006511 | Ubiquitin-dependent protein catabolism | 104 | 36 (23/13) | 0.000 | 1.000 |
GO:0006396 | RNA processing | 341 | 118 (64/54) | 0.011 | 0.995 |
GO:0006397 | mRNA processing | 217 | 74 (44/30) | 0.002 | 0.999 |
GO:0008380 | RNA splicing | 183 | 67 (39/28) | 0.000 | 1.000 |
GO:0006281 | DNA repair | 168 | 40 (23/17) | 0.009 | 0.995 |
GO:0000398 | Nuclear mRNA splicing, via spliceosome | 155 | 54 (30/24) | 0.000 | 1.000 |
GO:0006364 | rRNA processing | 32 | 16 (3/13) | 0.000 | 1.000 |
GO:0006996 | Organelle organization and biogenesis | 367 | 83 (30/53) | 0.048 | 0.964 |
GO:0006886 | Intracellular protein transport | 263 | 62 (32/30) | 0.002 | 0.999 |
GO:0008624 | Induction of apoptosis by extracellular signals | 28 | 13 (2/11) | 0.000 | 1.000 |
GO:0006120 | Electron transport, NADH to ubiquinone | 24 | 10 (3/7) | 0.003 | 0.999 |
GO:0048247 | Lymphocyte chemotaxis | 3 | 3 (0/3) | 0.004 | 1.000 |
GO:0007242 | Intracellular signaling cascade | 879 | 105 | 0.989 | 0.016 |
GO:0007186 | GPCR protein signaling pathway | 448 | 39 | 1.000 | 0.000 |
GO:0007267 | Cell-cell signaling | 417 | 39 | 0.998 | 0.003 |
GO:0007243 | Protein kinase cascade | 231 | 24 | 0.997 | 0.005 |
GO:0045860 | Positive regulation of protein kinase activity | 41 | 1 | 0.999 | 0.006 |
GO:0007268 | Synaptic transmission | 203 | 18 | 0.999 | 0.001 |
GO:0007187 | G-protein signaling (cyclic nucleotide second messenger) | 73 | 4 | 0.999 | 0.004 |
GO:0050896 | Response to stimulus | 1,326 | 179 | 0.975 | 0.035 |
GO:0009605 | Response to external stimulus | 781 | 90 | 0.972 | 0.037 |
GO:0009617 | Response to bacteria | 37 | 0 | 1.000 | 0.001 |
GO:0007601 | Visual perception | 126 | 9 | 0.999 | 0.002 |
GO:0007606 | Sensory perception of chemical stimulus | 55 | 2 | 0.999 | 0.003 |
GO:0007275 | Development | 1,412 | 174 | 0.992 | 0.011 |
GO:0009887 | Organogenesis | 770 | 89 | 0.997 | 0.004 |
GO:0007417 | Central nervous system development | 92 | 6 | 0.999 | 0.004 |
GO:0008544 | Epidermis development | 39 | 1 | 0.999 | 0.008 |
GO:0050875 | Cellular physiological process | 3,372 | 515 | 1.000 | 0.000 |
GO:0050874 | Organismal physiological process | 1,200 | 138 | 0.997 | 0.004 |
GO:0006813 | Potassium ion transport | 139 | 3 | 1.000 | 0.000 |
GO:0030003 | Cation homeostasis | 52 | 1 | 1.000 | 0.001 |