Primary and secondary transcriptional effects in the developing human Down syndrome brain and heart

Table 3 Nested cross-validation results using chromosome 21 genes

Pass	Number of samples	Best inner C-V score (% correct)	Number of tied models	Outer C-V score (% correct)
Subject 1	3	100.00% (22/22)	116	100.00%
Subject 2	2	100.00% (23/23)	160	100.00%
Subject 3	4	100.00% (21/21)	119	100.00%
Subject 4	4	100.00% (21/21)	142	99.82%
Subject 5	4	100.00% (21/21)	107	100.00%
Subject 6	1	100.00% (24/24)	131	100.00%
Subject 7	4	100.00% (21/21)	247	99.60%
Subject 8	1	100.00% (24/24)	186	100.00%
Subject 9	1	100.00% (24/24)	107	100.00%
Subject 10	1	100.00% (24/24)	212	100.00%
			Accuracy estimate	99.91%

The model space parameters are as follows: Gene selection: ANOVA; Number of genes: 1, 3, 5, ..., 251, 253; Classifier 1: K-Nearest Neighbor (KNN); Number of neighbors (K): 1, 3, 5; Similarity measures: Euclidean distance, Pearson's correlation, Absolute value (also known as 'City block'); Classifier 2: Nearest Centroid, Prior probability: Equal; Classifier 3: Discriminant Analysis, Discriminant functions: Linear, Quadratic, Prior probability: Equal.

ISSN: 1474-760X