Figure 1

The structure of the nuclear pore complex. Schematic representation of the position of the major nucleoporin subcomplexes in (a) unikonts and (b) bikonts. The schematic organization of the NPC in unikonts is based on the schematic organizations of NPC in vertebrates published by Powers and Dasso [15], completed accordingly with recent works [5,19]. Boxes delimited by dashed lines indicate proteins having unkown or no precise localization within or around the NPC. Light gray boxes represent nucleoporins present in unikonts but having no homologs in bikonts. Protein names in black in (a) indicate proteins having homologs in fungi, whereas those in red indicate proteins having no homologs but structural analogues in fungi. Lines between subcomplexes indicate putative interactions whereas double lines indicate undisputable interactions.