Table 1 Genomic organization of the human caveolin genes and properties of their protein products
From: The caveolin proteins
Human gene | Chromosomal location | Exon | Exon size (bp) | Intron | Intron size (kb) | Residues encoded by exon | Length of protein (amino acids) | Percentage similarity (identity) to human Cav-1 | Percentage similarity (identity) to human Cav-2 | Expression patterns |
|---|---|---|---|---|---|---|---|---|---|---|
Cav-1 | 7q31.1 | 1 | 30 | 1 2 3 | 1.47 31.8 | 1-10 11-65 66-178 | 178 | - | 59 (40) | Ubiquitous; highest levels in adipocytes, endothelia, smooth muscle cells, and Type I pneumocytes |
Cav-2 | 7q31.1 | 1 2a 2b | 150 188 151 | 1 2 | 0.33 5.76 | 1-50 51-112 113-162 | 162 | 58 (38) | - | Co-expressed with Cav-1 |
Cav-3 | 3p25 | 1 2 | 114 342 | 1 | ? | 1-38 39-151 | 151 | 85 (65) | 60 (39) | Muscle-specific; primarily in skeletal and cardiac myocytes |