Evidence from comparative genomics for a complete sexual cycle in the 'asexual' pathogenic yeast Candida glabrata

Table 1 Numbers of C. glabrata and K. delphensis orthologs found in different YPD 'cellular role' categories

YPD 'cellular role' categories	C. glabrata	K. delphensis	CG/SC*	KD/SC^†	S. cerevisiae ^‡
Aging	16	15	0.41	0.38	39
Amino acid metabolism	92	96	0.42	0.44	217
Carbohydrate metabolism	70	84	0.28	0.33	254
Cell adhesion	1	3	0.25	0.75	4
Cell cycle control	96	91	0.45	0.43	213
Cell polarity	91	97	0.42	0.45	216
Cell stress	98	114	0.30	0.34	331
Cell structure	51	51	0.43	0.43	120
Cell wall maintenance	68	75	0.37	0.41	184
Chromatin/chromosome structure	111	119	0.41	0.43	274
Cytokinesis	21	26	0.53	0.65	40
Differentiation	36	25	0.35	0.24	104
DNA repair	59	76	0.38	0.49	154
DNA synthesis	53	55	0.51	0.53	104
Energy generation	107	103	0.37	0.36	290
Lipid and sterol metabolism	76	99	0.37	0.48	206
Mating response^§	45	54	0.34	0.41	132
Meiosis^§	56	56	0.38	0.38	147
Membrane fusion	15	16	0.38	0.40	40
Mitochondrial transcription	3	4	0.60	0.80	5
Mitosis	72	73	0.49	0.50	147
Nuclear-cytoplasmic transport	49	48	0.53	0.52	92
Nucleotide metabolism	26	35	0.27	0.37	95
Other	27	26	0.47	0.46	57
Other metabolism	62	71	0.32	0.37	192
Phosphate metabolism	8	9	0.31	0.35	26
Pol I transcription	14	14	0.47	0.47	30
Pol II transcription	148	158	0.39	0.41	384
Pol III transcription	15	19	0.38	0.49	39
Protein complex assembly	22	20	0.47	0.43	47
Protein degradation	86	90	0.47	0.49	183
Protein folding	33	42	0.36	0.46	91
Protein modification	99	106	0.40	0.43	246
Protein synthesis	99	106	0.27	0.28	373
Protein translocation	37	31	0.43	0.36	87
Recombination	29	39	0.33	0.44	88
RNA processing/modification	126	144	0.45	0.51	280
RNA splicing	44	50	0.38	0.43	116
RNA turnover	19	28	0.37	0.54	52
Signal transduction	54	55	0.40	0.41	135
Small molecule transport	138	144	0.34	0.35	407
Vesicular transport	136	146	0.45	0.48	305
		Average	0.40	0.44

*Proportion of S. cerevisiae genes in the category with orthologs in C. glabrata. ^†Proportion of S. cerevisiae genes in the category with orthologs in K. delphensis. ^‡Number of S. cerevisiae genes assigned to the category in the YPD database. ^§Lists of the mating response and meiosis genes identified in C. glabrata and K. delphensis are given in the additional data file.

ISSN: 1474-760X