Computational discovery of sense-antisense transcription in the human and mouse genomes

Table 4 Orthologous mouse and human candidates

Human candidate	Mouse candidate	Sense gene	Antisense gene or homolog
Hs.250697	Mm.826	TC10	PIGF
Hs.211601	Mm.4358	MAP3K12	No protein match
Hs.2210	Mm.10167	FLJ22865	TRIP3
Hs.296776	Mm.20848	RFXANK	LOC126382
Hs.170263	Mm.25231	TP53BP1	No protein match
Hs.330310	Mm.176845	KIAA0632	G10
Hs.343244	Mm.10698	AP1G2	No protein match

Seven pairs of mouse and human candidate UniGene clusters that contain clear orthologs are listed. In the first six, the location, coding potential/identity, and pattern of overlap of the sense and antisense RNA species are consistent between the mouse and human candidates. Thus, in the first example, a sub-region of the terminal exon of Ras-like protein overlaps the full terminal exon of a class F phosphatidylinositol glycan (Hs.250697 and Mm.826). In the second example, the 3' UTR of MAPKKK12 is overlapped by a transcript with no protein homologies in both mouse and human; moreover, this non-coding region of overlap is highly conserved at nucleotide level between mouse and human (Hs.211601 and Mm.4358).

ISSN: 1474-760X