Table 1 Acetylated proteins and the corresponding acetyltransferases that act either cotranslationally (Co) or post-translationally (Post)
Acetylated proteins | Residues | Process | Acetyltransferases | References |
|---|---|---|---|---|
Majority of eukaryotic proteins | α-Ser, α-Ala, and so on | Co | NatA, NatB, and NatC | Reviewed in [3] |
E. coli ribosomal proteins (S18, S5, and L12) | α-Ser, α-Ala | Post | RimI, RimJ, and RimL | [4,5] |
Regulatory peptides (β-endorphin, α-MSH, enkephalin, GHRF) | α-Tyr, α-Ser, and α-Ala | Post | Unknown | [6,17] |
Histones (H2A, H2B, H3, H4) | ε-Lys | Co and Post | GNAT group: Gcn5, PCAF, Hat1, Elp3, and Hpa2 | Reviewed in [7,21,25] |
MYST group: Esa1, MOF, Sas2, Sas3, Tip60, and MORF | ||||
p300/CBP group | ||||
Transcription factor group: TAFII250 and TFIIIC | ||||
Nuclear receptors cofactors group: ACTR and SRC1 | ||||
Transcription factors (p53, E2F1-3, EKLF, TFIIEβ, TFIIF, c-Jun, TCF, GATA1, MyoD, HMGI(Y), pRb, NF-E2(MafG) and ACTR) | ε-Lys | Post? | PCAF/GCN5, p300/CBP, TAFII250, SRC1?, MOZ, Tip60? and BRCA2? | Reviewed in [8,24] |
HMG proteins (HMG1 and HMG2) | ε-Lys2 and ε-Lys11 | Unknown | p300/CBP and PCAF | [27,28] |
Nuclear receptor HNF-4 | ε-Lys | Unknown | p300/CBP | [32] |
Nuclear import factors (importin-α7 and Rch1) | ε-Lys22 | Post | p300/CBP | [9] |
α-tubulin | ε-Lys40 | Post | 62-67 kDa protein | [10,41] |