Structural maintenance of chromosomes (SMC) proteins, a family of conserved ATPases

Table 1 The six conserved eukaryotic core SMC proteins

	SMC1	SMC2	SMC3	SMC4	SMC5	SMC6
Protein length (in amino acids)	1233	1197	1217	1288	1101	1091
Accession number	AAB34405	XP_050024	AAC14893	BAA73535	CAC39247	CAC39248
Locus^*	Xp11.22-p11.21	9q22.31-q22.33	10q25	3q26.1	9q12	2p23-24
Homologs:
S. cerevisae	SMC1	SMC2	SMC3	SMC4	YOL034w	RHC18
S. pombe	psm1	cut14	psm3	cut3	spr18	rad18
C. elegans	T34063	Mix1	T31550	T21809	AAK31464	CAB16920
D. melanogaster	AAF56231	AAF58197	dCAP	Gluon	AAF51749	AAF56254
Xenopus laevis	XSMC1	XCAP-E	XSMC3	XCAP-C	-	-
Mus musculus	SmcB	-	SmcD	-	-	SMC6
A. thaliana	CAB77587	TITAN3	AAD26882	BAB10693	T51375	MIM

The length of the human proteins, their GenBank accession numbers and map positions are shown at the top of the table. ^*Mapping data for SMC1-SMC4 is from the Map Viewer at the National Center for Biotechnology Information (NCBI) [24], and for SMC5 and SMC6 is from [8]. Homologs from a range of species are shown below the data for human SMCs. Characterized genes are in italics, and the accession numbers of related proteins from genome sequence data found by BLAST searching are included; - indicates that no sequence has been found.

ISSN: 1474-760X