Table 1 Properties of human BIRPs

XIAP/MIHA/

57

Xq25

Detected in all adult tissues examined

hILP/BIRC4

cIAP-1/MIHB/

70

11q22-q23

Detected in all adult tissues examined,

HIAP2/BIRC2

with highest levels in thymus, testis

and ovary

cIAP-2/MIHC/

68

11q22-q23

Detected in all adult tissues examined,

In marginal zone cell lymphomas of

HIAP1/BIRC3

with highest levels in spleen and

the mucosa-associated lymphoid tissue,

thymus

API2, the gene encoding cIAP-2, is often

rearranged together with the novel gene

MLT at 18q21 resulting in an API2-MLT

fusion

LIVIN/ML-IAP/

31

20q13.3

Detected in embryonic tissue

The region is frequently amplified in

KIAP/BIRC7

and some adult tissues.

melanomas, colon, lung and colorectal

Elevated levels in cancer cell

malignancies

lines, particularly melanoma cell lines

NAIP/BIRC1

156

5q13.1

Detected only in liver and placenta

Deletions of the NAIP genes often occur

(6 genes)

by northern blot analysis but was

in individuals with spinal muscular atrophy

detected in spinal cord mRNA by

but deletions in the nearby gene SMN are

RT-PCR

the most likely cause of disease

Survivin/BIRC5

17

17q25

Cell-cycle-dependent expression,

restricted to tissues in which there are

dividing cells; for example, embryonic

tissue, solid tumors and transformed

cell lines. Expression is absent from

most normal adult tissue

BRUCE/BIRC6

528

2p21-p22

Expression of mRNA is detectable in

most adult tissues, with high levels in

brain and kidney