Figure 4
From: Evaluation of normalization procedures for oligonucleotide array data based on spiked cRNA controls
Noise distributions (CV) for the experimental and simulated data sets. (a) 0-hour dataset; (b) simulated dataset. Simulation noise parameters were iteratively estimated from the real data (see Materials and methods). The resulting distributions were sufficiently similar to allow the use of simulations to explore the effects of different sorts of noise on normalization methods.