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Fig. 4 | Genome Biology

Fig. 4

From: Profiling the immune epigenome across global cattle breeds

Fig. 4

CpG islands of elevated methylation divergence between populations, on average, show elevated genetic divergence. A The mean identity by state of CGIs showing different levels of methylation divergence between the Holstein Friesian and Nelore animals when looking across all cell types together. Standard errors of means are shown. CGIs of comparatively elevated methylation divergence generally also show elevated genetic divergence (lower IBS) compared to other CGIs between this pair of populations (shown in green). In contrast methylation divergence between the populations is largely not associated with the IBS scores calculated within the individual populations (shown in grey). B Association between IBS (left) or FST scores (right) and methylation divergence by cell types and population comparison. Each cell indicates the strength of association between the methylation divergence in a particular cell type and population comparison (rows) and the genetic divergence between a pair of populations (columns). Significant associations (corrected FDR P < 0.05) are shown in yellow/red, with insignificant results in white/blue. Abbreviations correspond to the following: HF = Holstein Friesian, ND = N’Dama, NL = Nelore, Ind = Bos indicus

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