The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection

Table 1 Amino acid coverage at positions NSP12-323 and spike-614 in the SARS-CoV-2 Victoria/01/2020 stock

Protein	Amino acid position	Read coverage	Variant	Number of reads	Proportion
NSP12	323	33629	P	33,423	0.9939
			L	10	0.0003
			others	196	0.0058
Spike	614	41047	D	40,901	0.9964
			G	7	0.0002
			others	139	0.0034

The number of reads per P, L, and other amino acids and per D, G, and other amino acids at positions 323 in NSP12 and 614 in the spike protein respectively were determined by ARTIC-Illumina sequencing of the Victoria/01/2020 stock

ISSN: 1474-760X