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Fig. 1. | Genome Biology

Fig. 1.

From: The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection

Fig. 1.

Sequence analysis and amino acid substitution in NSP12 (P323L) and the spike protein (D614G) between the first and third days of sampling in a patient hospitalized with COVID-19. Three different sequencing approaches were used: A an ARTIC-Illumina approach and B a RSLA-Nanopore approach to show the amino acid variation frequencies of NSP12 (at codon position 323) and spike protein (codon position 614). C Sanger sequence analysis of the amplicons used to investigate the change of dominant viral genome sequence around the sites within NSP12 (codon position 323) and spike protein (codon position 614). These samples were gathered under the auspices of ISARIC 4C

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