Fig. 6

Association between RBP-associated RNA editing events and alternative splicing. A Enrichment of the RBP-associated intragenic RNA editing events in K562 near the intron and exon ends. The sequences near the exon and intron ends were binned into 200-nt blocks. The numbers of editing sites located in each block are coded by a blue gradient. P-values indicating the significance of the enrichment were estimated by Fisher’s exact test. B For the RBP-associated RNA editing sites falling in gene bodies, the sites related to the AS events upon RBP knockdown were counted. See the “Methods” section for the identification of the AS-associated RNA editing sites. C Enrichment of UPF1-associated RNA editing sites by AS-related editing events upon ADAR knockdown. The other sites falling in the UPF1 eCLIP peaks but not showing significantly differential editing levels between eCLIP and RNA-seq, i.e., “Other UPF1-binding sites,” were used for comparison by Fisher’s exact test. D RNA splicing reporter assays showing patterns of alternative splicing upon editing at an intronic editing site, under the conditions of control or knockdown of UPF1 in HepG2 cells