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Fig. 5 | Genome Biology

Fig. 5

From: Survey of the binding preferences of RNA-binding proteins to RNA editing events

Fig. 5

Secondary structure changes upon RBP-associated RNA editing in the 3′ UTR. A The predicted minimum free energy (MFE) difference of the 3′ UTR sequences harboring the RBP-associated RNA editing sites before and after RNA editing. The PARS-seq data of HepG2 cells upon ADAR1 knockdown were used as a constraint. B Comparison between the distribution of the MFE change shown in panel A for the 3′ UTR sequences harboring the RBP-associated RNA editing sites (Sig) and the distribution for the 3′ UTR sequences harboring the similar numbers of editing sites that fall in the RBP-bound RNA regions but its editing not significantly associated with the RBPs (notSig). The P-value was calculated with the Wilcoxon test. C As an example, predicted secondary structures after (left and green lines in the arc diagram) and before (right and blue lines in the arc diagram) RNA editing of uc002ufm.3 3′ UTR

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