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Fig. 5 | Genome Biology

Fig. 5

From: Network propagation-based prioritization of long tail genes in 17 cancer types

Fig. 5

PPI network analysis of the relationships between UMGs (white nodes) and known driver genes (red) in breast invasive carcinoma (BRCA) suggests roles of UMGs. Driver genes are split into categories based on initial mutation score and node degree: (i) high score, high degree (bottom left); (ii) high score, low degree (top left); (iii) low score, low degree (top right); and (iv) low score, high degree (bottom right). UMGs connected to driver subsets (i) and (ii) (olive and orange edges) and ones with no mutation score (e.g., POLR2E) are likely to be drug targets. UMGs connected to (iii) and (iv) and ones without connections to drivers (top right corner, e.g., DSN1) are likely to be “weak drivers.” Other cancer types’ results are available in Additional file 5: Figs. S4-19

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