Fig. 2

ERIZs are located in non-transcribed regions within active compartments. a Percentage of the width of ERIZs in the A compartments. Genome represents the percentage of A compartments in the hg19 genome in the indicated cells. b The relationship between the peaks of predictors and ERIZ appearance in GM12878 and K562 cells (see “Methods” for details). c Distribution of ERIZs in the context of active transcription in GM12878 cells. “+” indicates the forward strand and “–” indicates the reverse strand. The positions and transcribed direction of genes are shown at the bottom of the panel with the gene names. Forward-transcribed genes are marked in orange and reverse-transcribed genes are marked in blue. d Heatmaps of ERIZ-associated early replication initiation (from EdU/HU, red) and active transcription (blue) in GM12878 and K562 cells. The ERIZ-occupied non-transcribed regions (non-TRs) are ranked by width and centered on the midpoint flanked by two transcribed genes in each cell line. The non-TRs in A compartments, 20–100 kb in width, are displayed. Each line represents a non-TR