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Table 1 Average run-time across all contrasts. Gene sets used are Broad MSigDB gene sets from the ChAMP package. All methods were run on a Blade Server: 24 CPUs - Intel(R) Xeon(R) Gold 6126 CPU @ 2.60GHz

From: Gene set enrichment analysis for genome-wide DNA methylation data

Method

Time (minutes)

1 core

10 cores

20 cores

mRRA (ORA)

0.13

-

-

GOmeth

0.54

-

-

mRRA (GSEA)

3.04

-

-

mGLM

47.95

16.12

9.86

ebGSEA

50.12

36.07

33.79