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Fig. 2 | Genome Biology

Fig. 2

From: MARS: leveraging allelic heterogeneity to increase power of association testing

Fig. 2

Comparison of eGenes identified by MARS and eGenes reported by GTEx consortium. a The plot shows that MARS controls type I error. The points represent 10 different gene loci used for the test where the five gene loci are from eGenes as reported by the GTEx consortium. b Box plot showing the percentage of power improvement of MARS over the univariate test for different effect sizes of two causal SNPs that exist in the data. The X-axis shows five different effect sizes of λ=4,4.5,5,5.5, and 6 used for the test. The Y-axis shows the percentage of power improvement. The red and black bars show the power improvement when loci not reported and reported as eGenes by the GTEx consortium are used for the test, respectively. c Plot comparing the percentage of power improvement of MARS over the univariate test when two and three causal variants implanted in the simulation data. Each variant has an effect size of λ=4.5.d Box plot showing the power of MARS, DAP-G, and fastBAT for different effect sizes. The X-axis shows the effect sizes of λ=2,2.5,3,3.5,4,4.5,5,5.5, and 6 used for the test. The Y-axis shows the power in percentages. The red, green, and blue boxplots show the power of MARS, DAP-G, and fastBAT, respectively

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