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Fig. 5 | Genome Biology

Fig. 5

From: Human brain region-specific variably methylated regions are enriched for heritability of distinct neuropsychiatric traits

Fig. 5

Neuronal CG-DMRs and VMRs are highly enriched for explained heritability of multiple psychiatric, neurological, and behavioral-cognitive traits. Results from running stratified linkage disequilibrium score regression using 30 GWAS traits with 97 baseline features and either DMRs (a) or VMRs (b) identified in this study. Only feature-trait combinations with a coefficient z-score significantly larger than 0 (one-sided z-test with alpha = 0.05, P-values corrected within each trait using Holm’s method) are shown. Enrichment score (y-axis) and coefficient z-score (x-axis) from running this analysis for each of the indicated methylation features combined with the baseline features are plotted

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Genome Biology

ISSN: 1474-760X

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