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Fig. 2 | Genome Biology

Fig. 2

From: Functional and genetic determinants of mutation rate variability in regulatory elements of cancer genomes

Fig. 2

Comprehensive map of mutational processes in gene-regulatory and chromatin architectural elements of cancer genomes. a Comparison of mutation frequencies in DNA-binding sites of the CTCF chromatin architectural factor (left), transcription start sites (TSS) and cancer-specific open-chromatin sites in 2419 whole cancer genomes (FDR < 0.05). Total mutations (SNVs, indels) and mutations grouped by single-base substitution (SBS) signatures, substitution types and DNA strand were analysed. Open-chromatin sites were filtered to exclude TSSs and CTCF sites. b–e Examples of localised mutation frequencies and signatures: b Enrichment of SBS17B in CTCF binding sites in oesophageal adenocarcinoma, c pan-cancer enrichment of SBS3 mutations in TSSs, d enrichment of SBS40 mutations in open-chromatin sites in prostate adenocarcinoma, e pan-cancer depletion of indel mutations in open-chromatin sites

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