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Fig. 4 | Genome Biology

Fig. 4

From: 547 transcriptomes from 44 brain areas reveal features of the aging brain in non-human primates

Fig. 4

Weighted gene co-expression network analysis (WGCNA). a In total, 56 modules were identified by WGCNA. b Significant (FET p value after correcting for number of modules and functional categories/pathways tested) enrichment of functional categories in modules with gains of connectivity. Y-axis represents – log (p value) of enrichment; x-axis denotes number of genes per module. c Circos plots displaying degree of enrichment for DEGs in aged-brain modules. Outermost rectangle is an arbitrary color for module name, followed by MDC score and then by importance (a measure considering degree of enrichment for DEGs across brain regions). Innermost concentric circles represent degree to which DEGs are contained within a given module for each brain region. d Circos plots displaying degree of enrichment for cell types in aged-brain modules. Outermost rectangle is an arbitrary color for module name, followed by importance (a measure considering degree of enrichment for cell types). Innermost concentric circles represent enrichment for genes with fivefold higher expression in oligodendrocyte, neuron, microglia, endothelial, or astrocyte cell types (Zhang et al. [94]) in aged-brain modules. e Functional enrichment of genes in brown module. f Network plot of hub genes identified within brown module. Blue nodes indicate all genes. Red nodes indicate hub genes. Yellow halos indicate aged-specific hub genes. Cyan node indicates gene PGLS for functional validation. Edges reflect significant interactions between genes based on mutual information

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