Fig. 7

Assignment of activity pattern for the comparison of two conditions. For the differential comparison of enhancers in two conditions, C¹ and C², the activity pattern assigned to bin _x depends on the empirical p values of bin _x and two neighboring bins to both sides (bin _x−1, bin _x−2, bin _x+1, bin _x+2). If one of the five empirical p values exceeds the cutoff P^∗, bin _x does not represent a differential enhancer between C¹ and C² and is assigned the activity pattern {T_x(C¹,C²)=0, T_x(C²,C¹)=0}={0,0}. If all five bins show an empirical p value below P^∗ and the group mean of C¹ is greater than the group mean of C² (μC¹>μC², bin _x represents an active enhancer in C¹ and is assigned the activity pattern {T_x(C¹,C²)=1, T_x(C²,C¹)=0}={1,0}. In the opposite case (μC²>μC¹), bin _x is active in C² with an activity pattern of {T_x(C¹,C²)=0, T_x(C²,C¹)=1}={0,1}