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Fig. 5 | Genome Biology

Fig. 5

From: methylCC: technology-independent estimation of cell type composition using differentially methylated regions

Fig. 5

methylCC accurately estimates cell composition of DNAm samples measured on WGBS platforms. Cell composition estimates using N=44 WGBS samples from the BLUEPRINT Epigenome Database [23] from seven purified whole blood cell types, specifically B cells, CD4T cells, CD8T cells, neutrophils, eosinophils, monocytes, and natural killer cells. For a given WGBS sample (e.g., CD8T cells), we assumed the “gold standard” cell composition to be 100% CD8T cells and 0% for the other cell types. We fit our model to N=44 purified cell types measured on the WGBS platform

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