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Fig. 1 | Genome Biology

Fig. 1

From: CRISPR-SKIP: programmable gene splicing with single base editors

Fig. 1

CRISPR-SKIP targeting strategy. a The consensus sequence of splice acceptors. We hypothesize that base editing of the highly conserved G (asterisk) leads to exon skipping. b In the presence of an appropriate PAM sequence, base editors can be utilized to deaminate the cytidine in the antisense strand, which is complementary to the conserved guanosine in the splice acceptor, thus resulting in the disruption of the splice acceptor and exon skipping

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