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Fig. 5 | Genome Biology

Fig. 5

From: Tensorial blind source separation for improved analysis of multi-omic data

Fig. 5

Tensorial ICA identifies components enriched for mQTLs in an EWAS of purified cell types. a Left panel: Bar plot of the odds ratio (OR) of enrichment of the top-ranked 500 CpGs for mQTLs in each of the 11 ICs and cell types, as indicated. Right panel: Corresponding heat map indicating the P values of enrichment as estimated using a one-tailed Fisher’s exact test. b Heat maps of enrichment P values of the top-ranked 500 CpGs from each IC for chromosomes. The significance of P values is indicated in different colours using same scheme as in a. c An example of a cell-type-independent mQTL mapping to chromosome 1. Plots show the weights of the corresponding components for B cells, T cells and monocytes, with the selected CpGs mapping to the mQTL indicated in red. d Validation of the mQTL in c in an independent blood-buccal EWAS. f Venn diagram showing the overlap of mQTLs derived from the ICs in the purified cell-type EWAS with those derived from the blood-buccal EWAS. The odds ratio (OR) and one-tailed Fisher test P value of the overlap are given. Chr chromosome, EWAS epigenome-wide association study, IC independent component, mQTL methylation quantitative trait locus, OR odds ratio

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