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Fig. 5 | Genome Biology

Fig. 5

From: Hepatic steatosis risk is partly driven by increased de novo lipogenesis following carbohydrate consumption

Fig. 5

a Body mass of mice over the duration of the dietary intervention. WT mice fed low fat chow (LFC) were significantly lighter than those fed a Western diet (WD) from 6 weeks onward (p < 0.05; n = 8). b Histological assessment of hepatic steatosis. Masson’s trichrome stained sections were used for histological analysis and lipid content assessed as the average percentage of the hepatic tissue that appeared as unstained lipid droplets. Mice fed a LFC diet had significantly lower lipid content than mice fed WD. Mean ± SEM analysed by two-way ANOVA and Tukey’s multiple comparison test. c Overall quantity of DNL synthesised palmitate. Mice fed a WD demonstrate significantly increased production of palmitate compared to those fed LFC. Mean ± SEM analysed by two-way ANOVA and Tukey’s multiple comparison test. d LC-MS analysis of intact TAGs within the liver and blood plasma. TAGs that were significantly increased in each group were plotted by number of carbon atoms against number of double bonds within the FA moieties, when compared pairwise using PLS-DA with a VIP > 1 being taken as significant

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